![]() Identifies the first instructive signal required for organizer function.īachiller, D. Neural and head induction by insulin-like growth factor signals. Endogenous Cerberus activity is required for anterior head specification in Xenopus. Provides evidence that head induction is the result of triple inhibition of Nodal, bone morphogenetic proteins and Wnt signals. The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. Anterior identity is established in chick epiblast by hypoblast and anterior definitive endoderm. Shows that the role of Nodal antagonists is to negatively regulate mesoderm formation.Ĭhapman, S. Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks. Positive and negative signals modulate formation of the Xenopus cement gland. Anterior patterning by synergistic activity of the early gastrula organizer and the anterior germ layer tissues of the mouse embryo. Reconciling different models of forebrain induction and patterning: a dual role for the hypoblast. Shows that head-organizer activity is predominatly located in presumptive prechordal mesendoderm, rather than the anterior endoderm.įoley, A. Spatially distinct head and heart inducers within the Xenopus organizer region. ![]() Axis development and early asymmetry in mammals. The role of prechordal mesendoderm in neural patterning. Molecular interactions continously define the organizer during the cell movements of gastrulation. Discovery of tail-inducer activity outside the Spemann–Mangold organizer and identification of the involvement of Wnt, bone morphogenetic proteins and Nodal signals. The molecular nature of the zebrafish tail organizer. Tail bud determination in the vertebrate embryo. Refutes the view that head-organizer activity in the mouse resides exclusively in the anterior visceral endoderm shows that definitive anterior mesendoderm that is derived from the primitive streak harbours head-organizer activity. The organizer of the mouse gastrula is composed of a dynamic population of progenitor cells for the axial mesoderm. Visceral endoderm mediates forebrain development by suppressing posteriorizing signals. Head induction in the chick by primitive endoderm of mammalian, but not avian origin. Shows that presumptive prechordal mesendoderm contains anterior neural-inducing activity.īeddington, R. Anterior mesendoderm induces mouse Engrailed genes in explant cultures. Axis-inducing activities and cell fates of the zebrafish organizer. Saude, L., Woolley, K., Martin, P., Driever, W. Anteroposterior patterning in the zebrafish, Danio rerio: an explant assay reveals inductive and suppressive cell interactions. Patterning of the chick forebrain anlage by the prechordal plate. Retinoid signalling in the development of the central nervous system. Fibroblast growth factor signalling during early vertebrate development. Initial patterning of the central nervous system: how many organizers? Nature Rev. Neural induction: toward a unifying mechanism. Shaping the vertebrate body plan by polarized embryonic cell movements. The vertebrate organizer (Springer, Berlin, Heidelberg, 2003). Spemann's organizer: models and molecules. The establishment of Spemann's organizer and patterning of the vertebrate embryo. Nodal is upstream of the orthogonal activity gradients of Wnt and BMP, which specify the anterior–posterior and dorsal–ventral axes the three growth-factor pathways cross-regulate each other.ĭe Robertis, E. In zebrafish, the tail organizer is composed of cells from the dorsal as well as the ventral side of the gastrula-stage embryo.ĭuring embryonic axis formation, BMP, Nodal and Wnt growth factors act in signalling gradients to pattern embryonic cells in a dose-dependent fashion. The tail organizer requires activity of BMP, Nodal and Wnt growth factors. The trunk organizer requires inhibition of BMP growth factors and expresses a corresponding set of BMP antagonists. The head organizer requires inhibition of BMP, Nodal and Wnt growth factors and expresses a corresponding set of growth-factor antagonists. Recent evidence indicates that both models apply. They have different cell compositions and express distinct genes.Ī long-standing question is whether the regionally specific inductions of the Spemann–Mangold organizer are the result of quantitative or qualitative mechanisms. Head, trunk and tail organizers can be distinguished on the basis of transplantation experiments in all vertebrates. It coordinates pattern formation along the anterior–posterior, dorsal–ventral and left–right axes. The Spemann–Mangold organizer is an axis-inducing centre that is evolutionarily conserved in vertebrates.
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